The previous two STRUCTURE magazine articles (General Principles of Fatigue and Fracture, Part 1, August 2016 and AISC and Damage Tolerance Approaches, Part 2, November 2016), reviewed the fundamental principles of cracking and how to design for fatigue and fracture. This article presents three case studies that illustrate how an engineer can use this guidance to address project challenges. The intent of this article is to move from the theoretical to the practical, and demonstrate that there is a realistic place for the more developed methodologies of fatigue and fracture mitigation. …